GPI transamidase component PIG-S; phosphatidylinositol-glycan biosynthesis class S protein (PIGS)

Function: - component of the GPI transamidase complex - essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates - glycolipid biosynthesis; GPI-anchor biosynthesis - forms a complex with PIGK/GPI8, PIGT, PIGU & GAA1 Structure: belongs to the PIGS family Compartment: - endoplasmic reticulum membrane - multi-pass membrane protein Alternative splicing: named isoforms=2

General

phosphatidylinositol-glycan biosynthesis protein (PIG-protein) transmembrane 2 protein

Properties

SIZE: entity length = 555 aa MW = 62 kD COMPARTMENT: endoplasmic reticulum MOTIF: cytoplasmic domain {2-18} transmembrane domain {19-39} exoplasmic loop {40-520} MOTIF: N-glycosylation site {N267} N-glycosylation site {N370} transmembrane domain {521-541} cytoplasmic domain {542-555}

Database Correlations

OMIM 610271 UniProt Q96S52 Pfam PF10510 Entrez Gene 94005 Kegg hsa:94005

References

UniProt :accession Q96S52