PTB-containing, cubilin & LRP1-interacting protein (P-CLI1, phosphotyrosine interaction domain-containing protein 1, protein NYGGF4, PID1, NYGGF4, PCLI1, HMFN2073)

Function: - increases proliferation of preadipocytes without affecting adipocyte differentiation - found in a complex with PID1/PCLI1, LRP1 & CUBNI - interacts with LRP1 & CUBN Structure: contains 1 PID domain Alternative splicing: named isoforms=4 Expression: - expressed in subcutaneous fat, heart, skeletal muscle, brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung & peripheral blood leukocyte - up-regulated in fat of obese subjects Polymorphism: some sequences seem to have a duplication of exon 2

Properties

SIZE: MW = 28 kD entity length = 250 aa COMPARTMENT: cytoplasm MOTIF: phosphotyrosine interaction domain NAME: phosphotyrosine interaction domain SITE: 93-250 MOTIF: Ser phosphorylation site {S236}

References

UniProt :accession Q7Z2X4