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phosphatidylinositol 3 kinase catalytic subunit delta (PIK3CD)
Function:
- 3-phosphorylates cellular phosphoinositide Ptdins(4,5)P2 to produce Ptdins(3,4,5)P3
- heterodimer of a p110 (catalytic) & a p85 (regulatory) subunit
- interacts with ERAS (putative)
- carbohydrate metabolism; inositol phosphate metabolism
- autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Structure:
- belongs to the PI3/PI4-kinase family
- contains 1 PI3K/PI4K domain
Expression: expressed predominantly in leukocytes
Pharmacology:
- leniolisib (Joenja) FDA-approved for PI3K delta syndrome inhibits PI3K delta
General
PI-3-kinase p110
Properties
SIZE: entity length = 1044 aa
MW = 119 kD
MOTIF: PI3K/PI4K {774-1041}
MOTIF: Ser phosphorylation site {S1039}
Database Correlations
OMIM 602839
UniProt O00329
PFAM correlations
Entrez Gene 5293
ENZYME 2.7.1.153
References
UniProt :accession O00329