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phytoestrogen
Plant-derived non-steroidal compounds with weak estrogen-like activity. Most exist in the diet as inactive compounds, but undergo enzymatic activation in the gastrointestinal tract to compounds with a steroidal structure resembling estrogens. [2]
Classification:
4 classes of phytoestrogens
1) isoflavones
2) lignans
3) cumestrans
4) phytosterols
Indications:
- may be associated with diminished risk of lung cancer [2]
Contraindications:
- No benefit for post-menopausal hot-flashes [1]
Interactions
drug adverse effects of estrogens
Specific
cumestran
Foeniculum vulgare (fennel)
isoflavone
lignan; enterodiol; enterolactone
phytosterol
General
estrogen
References
- Journal Watch 23(14):113, 2003
Nikander E et al,
A randomized placebo-controlled crossover trial with
phytoestrogens in treatment of menopause in breast cancer
patients
Obstet Gynecol 101:1213, 2003
PMID: 12798527
- Schabath MB et al.
Dietary phytoestrogens and risk of lung cancer
JAMA 2005 Sep 28;294(12):1493-504
PMID: 16189362