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phosphorylase kinase
Function:
- catalyzes the phosphorylation of Ser in certain substrates, including troponin I
- allosteric regulation by Ca+2
- glycan biosynthesis; glycogen metabolism
Structure:
- polymer of 16 chains, four each of alpha, beta, gamma, & calmodulin (delta)
- alpha & beta are regulatory chains, gamma is the catalytic chain, & delta is calmodulin
Note:
- 3D-image of gamma subunit
Laboratory:
- phosphorylase kinase in erythrocytes
Related
glycogen storage disease type-IX
General
Ca+2/calmodulin-dependent protein kinase (CaM kinase)
multisubunit protein
Properties
SIZE: MW = 1300 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: S/T-phosphate
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
calmodulin binding site
EFFECTOR-BOUND: calmodulin
SUBUNITS: phosphorylase kinase-alpha (4)
phosphorylase kinase-beta (4)
phosphorylase kinase gamma (4)
MOTIF: S/T-phosphate
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
calmodulin binding site
EFFECTOR-BOUND: calmodulin
STATE: active state
calmodulin (4)
MOTIF: EF hand
S/T phosphorylation site
FOR-PHOSPHORYLATION-BY: casein kinase 2
peptide methylation site
MISC-INFO: DISTRIBUTION
:REGIONAL BROAD
:SUBCELLULAR CYTOSOLIC
SUBSTRATE-SPECIFICITY
:RANGE NARROW
RECOGNITION-MOTIF
:SEQUENCE KRKQI[S*]VR
:REF " - Kemp BE, Pearson RB.
Protein kinase recognition sequence motifs.
Trends Biochem Sci. 1990 Sep;15(9):342-6. Review.
PMID: 2238044"
References
- Nestler & Greengard Basic Neurochemistry ch 19 1989
- Textbook of Biochemistry with Clinical Correlations,
3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 347
- UniProt :accession P46020
Components
calmodulin
phosphorylase kinase gamma
phosphorylase kinase-alpha
phosphorylase kinase-beta