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phosphorylase-B (brain glycogen phosphorylase, PYGB)
Function:
- glycogen phosphorylase
- phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A
(1,4-alpha-D-glucosyl)(n) + phosphate
(1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate
Cofactor: pyridoxal phosphate
Structure:
- homodimer
- dimers associate into a tetramer to form the enzymatically active phosphorylase A
- belongs to the glycogen phosphorylase family
General
glycogen phosphorylase
Properties
CONFIGURATION: dimer
SIZE: entity length = 843 aa
MW = 97 kD
COMPARTMENT: cytoplasm
CELL: neuron
MOTIF: Ser phosphorylation site {S15}
binding site
SITE: 76-76
FOR-BINDING-OF: AMP
cysteine residue {109}
cysteine residue {143}
tyrosine residue {156}
Tyr phosphorylation site {Y197}
Tyr phosphorylation site {Y473}
cofactor-binding site [681-681]
FOR-BINDING-OF: pyridoxal phosphate
Database Correlations
OMIM 138550
UniProt P11216
Pfam PF00343
Kegg hsa:5834
ENZYME 2.4.1.1
References
UniProt :accession P11216