phospholipase C

Function: - production of the second messenger molecules diacylglycerol & inositol 1,4,5-trisphosphate (IP3)

Specific

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon 1 (phospholipase C-epsilon-1, PLC-epsilon-1, phosphoinositide-specific phospholipase C epsilon-1, pancreas-enriched phospholipase C, PLCE1, KIAA1516, PLCE, PPLC) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2; phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4; PLC-L4; phospholipase C-like protein 4; phospholipase C-eta-2; PLC-eta2 (PLCH2, KIAA0450, PLCL4) phospholipase C eta (PLC-eta) phospholipase C-alpha phospholipase C-beta phospholipase C-delta phospholipase C-gamma

General

Ca+2 binding protein guanine nucleotide regulatory protein [GNRP] effector phospholipase

Properties

COMPARTMENT: cytoplasm* CELL: most cell types* ORGANISM: mammal* MOTIF: binding site EFFECTOR-BOUND: G-alpha Ca+2-binding site STATE: active state

References

- Dennis EA, Rhee SG, Billah MM, Hannun YA. Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 1991 Apr;5(7):2068-77. Review. PMID: 1901288