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cardiac phospholamban; PLB (PLN, PLB)
Function:
- unphosphorylated form inhibits Ca+2-transporting ATPase of sarcoplasmic reticulum
- binding to cytoplasmic tail of ER Ca+2 ATPase inhibits pump
- phosphorylation by cAMP kinase (PKA) & CaM kinase inhibits inhibition of ER Ca+2 ATPase
- phosphorylated in response to beta-adrenergic stimulation
Structure:
- homopentamer
- belongs to the phospholamban family
Compartment:
- mitochondrial membrane
- sarcoplasmic reticulum (putative)
Expression: heart
Pathology:
- defects in PLN are the cause of dilated cardiomyopathy type 1P
Interactions
molecular events
General
phosphoprotein
Properties
SIZE: entity length = 52 aa
MW = 6 kD
COMPARTMENT: mitochondria
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S16}
Thr phosphorylation site {T17}
transmembrane domain {32-52}
Database Correlations
OMIM correlations
MORBIDMAP 172405
UniProt P26678
Pfam PF04272
Entrez Gene 5350
Kegg hsa:5350
References
- UniProt :accession P26678
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=PLN
- Cohen P.
Signal integration at the level of protein kinases, protein
phosphatases and their substrates.
Trends Biochem Sci. 1992 Oct;17(10):408-13. Review.
PMID: 1333658