Search
phosphoglycerate kinase 1 (primer recognition protein 2, PRP 2, cell migration-inducing gene 10 protein, PGK1, PGKA, MIG10, OK/SW-cl110)
Function:
- glycolytic enzyme
- polymerase alpha cofactor protein (primer recognition protein)
- carbohydrate degradation; glycolysis
- pyruvate from D-glyceraldehyde 3-phosphate, step 2/5
ATP + 3-phospho-D-glycerate ADP + 3-phospho-D-glyceroyl phosphate
Structure:
- monomer
- belongs to the phosphoglycerate kinase family
Compartment: cytoplasm
Pathology:
- defects in PGK1 are generally associated with chronic hemolytic anemia although it can be accompanied by either mental retardation or muscular disease (rhabdomyolysis)
General
phosphoglycerate kinase
Properties
SIZE: entity length = 417 aa
MW = 45 kD
COMPARTMENT: cytoplasm
MOTIF: Substrate binding {24-26}
binding site
SITE: 39-39
FOR-BINDING-OF: Substrate
Substrate binding {63-66}
binding site
SITE: 123-123
FOR-BINDING-OF: Substrate
Ser phosphorylation site {S136}
binding site
SITE: 171-171
FOR-BINDING-OF: Substrate
Tyr phosphorylation site {Y196}
Ser phosphorylation site {S203}
ATP-binding site
NAME: ATP-binding site
SITE: 220-220
ATP-binding site
NAME: ATP-binding site
SITE: 313-313
ATP-binding site
NAME: ATP-binding site
SITE: 344-344
ATP-binding site
NAME: ATP-binding site
SITE: 373-376
Ser phosphorylation site {S390}
Database Correlations
OMIM 311800
UniProt P00558
Pfam PF00162
Entrez Gene 5230
KEGG correlations
ENZYME 2.7.2.3
References
- UniProt :accession P00558
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=PGK1
- SHMPD; The Singapore human mutation & polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PGK1
- Wikipedia; phosphoglycerate kinase entry
http://en.wikipedia.org/wiki/phosphoglycerate_kinase