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phosphatidylethanolamine-binding protein 1 (PEBP-1, prostatic-binding protein, HCNPpp, neuropolypeptide h3, Raf kinase inhibitor protein, RKIP, [Contains: Hippocampal cholinergic neurostimulating peptide (HCNP)], PEBP1, PBP, PEBP)
Function:
- binds ATP, opioids & phosphatidylethanolamine
- lower affinity for phosphatidylinositol & phosphatidylcholine
- serine protease inhibitor
- inhibits thrombin, neuropsin & chymotrypsin but not trypsin, tissue type plasminogen activator & elastase
- precursor of hippocampal cholinergic neurostimulating peptide
- interacts with Raf-1 & seems to inhibit it
- HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system
- HCNP increases production of choline acetyltransferase but not acetylcholinesterase
- seems to be mediated by a specific receptor
Structure:
- belongs to phosphatidylethanolamine-binding protein family
Compartment: cytoplasm
General
phosphatidylethanolamine [PE]-binding protein
protein precursor
serine protease inhibitor; serpin
Properties
SIZE: entity length = 187 aa
MW = 21 kD
COMPARTMENT: cytoplasm
MOTIF: Thr phosphorylation site {T42}
Ser phosphorylation site {S52}
Ser phosphorylation site {S54}
INHIBITS: serine protease
Database Correlations
OMIM 604591
UniProt P30086
Pfam PF01161
Entrez Gene 5037
Kegg hsa:5037
References
- UniProt :accession P30086
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/PEBP1ID44021ch12q24.html