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phosphatidylethanol in blood
Indications:
- evaluation of alcohol consmption (within 1-4 weeks)
Reference interval:
- phosphatidylethanol in blood cutoffs: [2]
- light drinking: < 25 ng/mL
- moderate drinking: 25-200 ng/mL
- heavy drinking: > 200 ng/mL
- 18.5-20 ng/mL can be used in clinical care as a cutoff to detect heavy alcohol consumption in middle-age & older men* [1]
* sensitivity: 84%, specificity: 73%
General
toxicology/drug test
References
- Hahn JA, Fatch R, Barnett NP et al
Phosphatidylethanol vs Transdermal Alcohol Monitoring for Detecting Alcohol
Consumption Among Adults.
JAMA Netw Open. 2023;6(9):e2333182.
PMID: 37698861 PMCID: PMC10498325 Free PMC article
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809197
- Tavaglione F et al.
Clinical utility of phosphatidylethanol to detect underreported alcohol use
and enhance steatotic liver disease subclassification.
J Hepatol 2025 Jun 13;
PMID: 40517819
https://www.journal-of-hepatology.eu/article/S0168-8278(25)02269-X/abstract
- Torp N et al.
Phosphatidylethanol and self-reported alcohol intake to subclassify in
individuals at risk of steatotic liver disease: An analysis of data from
a prospective cohort study.
Lancet Gastroenterol Hepatol 2025 Sep 10; [e-pub].
PMID: 40945520
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00187-6/abstract