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phosphatase-2A B subunit

Function: - several forms of phosphatase 2A B subunit encoded by separate genes are found complexed with a single catalytic (PP2A-cat) & A subunit. - at least one form is specific for the nervous system [1] - the PP2A-B subunit appears to suppress the activity of PP2A - since ceramide activates heterotrimeric PP2A, but not PP2A-catalytic monomer or PP2A-cat/PP2A-A hetero-dimer, an allosteric site for binding of ceramide is included as a motif for the B subunit - binding of ceramide is suggested to inhibit PP2A-B inhibition of PP2A

Related

ceramide

Specific

phosphatase-2A 48 kD regulatory subunit B (PP2A, subunit B, PR48 isoform; PPP2R3B) phosphatase-2A 55 kD regulatory subunit B alpha; PP2A subunit B-B-alpha isoform; PP2A subunit B,-B55-alpha isoform; PP2A subunit B-PR55-alpha isoform; PP2A subunit B-R2-alpha isoform (PPP2R2A) phosphatase-2A 55 kD regulatory subunit B beta; PP2A subunit B-B-beta isoform; PP2A; subunit B-B55-beta isoform; PP2A subunit B-PR55-beta isoform; PP2A subunit B-R2-beta isoform (PPP2R2B) phosphatase-2A 55 kD regulatory subunit B gamma (PP2A, subunit B, B-gamma isoform; PP2A, subunit B, B55-gamma isoform; PP2A, subunit B, PR55-gamma isoform; PP2A, subunit B, R2-gamma isoform; IMYPNO1; PPP2R2C) phosphatase-2A 72/130 kD regulatory subunit B (PP2A, subunit B, B''-PR72/PR130; PP2A, subunit B, B72/B130 isoforms; PP2A, subunit B, PR72/PR130 isoforms; PP2A, subunit B, R3 isoform, PPP2R3A, PPP2R3) phosphatase-2A regulatory subunit B' (PP2A, subunit B', PR53 isoform, phosphotyrosyl phosphatase activator, PTPAD) phosphatase-2A regulatory subunit B' alpha (PP2A, B subunit, B' alpha isoform; PP2A, B subunit, B56 alpha isoform; PP2A, B subunit, PR61 alpha isoform; PP2A, B subunit, R5 alpha isoform; PPP2R5A) phosphatase-2A regulatory subunit B' beta (PP2A, B subunit, B' beta isoform; PP2A, B subunit, B56 beta isoform; PP2A, B subunit, PR61 beta isoform; PP2A, B subunit, R5 beta isoform; PPP2R5B) phosphatase-2A regulatory subunit B' delta (PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; PPP2R5D) phosphatase-2A regulatory subunit B' epsilon (PP2A, B subunit, B' epsilon isoform; PP2A, B subunit, B56 epsilon isoform; PP2A, B subunit, PR61 epsilon isoform; PP2A, B subunit, R5 epsilon isoform; PPP2R5E) phosphatase-2A regulatory subunit B' gamma (PP2A, B subunit, B' gamma isoform; PP2A, B subunit, B56 gamma isoform; PP2A, B subunit, PR61 gamma isoform, PP2; B subunit, R5 gamma isoform; renal carcinoma antigen NY-REN-29; PPP2R5C) serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B delta (PP2A, subunit B, B-delta isoform; PP2A, subunit B, B55-delta isoform; PP2A, subunit B, PR55-delta isoform; PP2A, subunit B, R2-delta isoform, PPP2R2D, KIAA1541)

General

protein subunit

Properties

MOTIF: binding site FOR-BINDING-OF: ceramide

References

  1. Goedert M. Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci. 1993 Nov;16(11):460-5. Review. PMID: 7507619
  2. Hannun YA, Obeid LM. Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci. 1995 Feb;20(2):73-7. Review. PMID: 7701566

Component-of

phosphatase-2A (ceramide-activated protein phosphatase)