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phlebotonic
heterogenous class of drugs consisting of plant extracts & synthetic compounds including:
- rutosides, hidrosmine, diosmine, calcium dobesilate, chromocarbe, Centella asiatica, disodium flavodate, grape seed extract, aminaftone, french maritime pine bark extract
Indications:
- chronic venous insufficiency
- lymphedema
- hemorrhoids
Mechanism of action:
- improve venous tone
- stabilize capillary permeability
- increase lymphatic drainage
General
vasoactive agent
References
- Perera N, Liolitsa D, Iype S et al
Phlebotonics for haemorrhoids.
Cochrane Database Syst Rev. 2012 Aug 15;(8):CD004322
PMID: 22895941
http://www.cochrane.org/CD004322/COLOCA_phlebotonics-for-haemorrhoids
- Martinez-Zapata MJ, Vernooij RW, Uriona Tuma SM
Phlebotonics for venous insufficiency.
Cochrane Database Syst Rev. 2016 Apr 6;4:CD003229.
PMID: 27048768