pleckstrin homology-like domain family B member 2 (protein LL5-beta, PHLDB2, LL5B)

Function: - role in assembly of postsynaptic apparatus (putative) - role in acetylcholine receptor aggregation in postsynaptic membrane - interacts with FLNC Structure: - contains 1 PH domain the mediates binding to phosphoinositides Compartment: - cytoplasm, peripheral membrane - translocates to plasma membrane at high levels of PIP3 - at low levels of PIP3 is translocated to vesicles Alternative splicing: named isoforms=3

General

phosphoprotein pleckstrin homology-like domain family B

Properties

SIZE: MW = 142 kD entity length = 1253 aa COMPARTMENT: cytoplasm MOTIF: Thr phosphorylation site {T404} Ser phosphorylation site {S489} coiled coil {584-696} coiled coil {722-807} Thr phosphorylation site {T898} Ser phosphorylation site {S980} coiled coil {1032-1098} PH domain {1143-1246}

Database Correlations

UniProt Q86SQ0 Pfam PF00169

References

UniProt :accession Q86SQ0