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Philadelphia chromosome-positive chronic myeloid leukemia (CML)

Epidemiology: - 90% of chronic myeloid leukemia (CML) Genetics: - chromosomal translocation t9q34.1:22q11 (Philadelphia chromosome) - a truncated c-abl is translocated from chromosome 9 to the bcr locus on chromosome 22 - the breakpoint on chromosome 9 ranges from 15-40 kb upstream from the first exon of the abl gene - breakpoints on chromosome 22 occur over ~5-6 kb referred to as the breakpoint cluster region (M-bcr) which contains exons 1-3 of the bcr gene

Related

abl proto-oncogene breakpoint cluster region protein P160 (p160BCR) chromosomal translocation t9q34.1:22q11 (Philadelphia chromosome; bcr/abl)

General

chronic myeloid leukemia (CML, granulocytic leukemia)

References

  1. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 288
  2. Beutler et el. Williams Hematology, McGraw-Hill, 5th ed. 1995 pg 300-1