PHF2-ARID5B complex

Function: - PHF2 mediates demethylation of methylated ARID5B - demethylation of ARID5B targets the PHF2-ARID5B complex to target promoters - acts as a coactivator of HNF4A in liver Structure: - subunits include: PHF2, ARID5B

Properties

SUBUNITS: PHD finger protein 2 COMPARTMENT: cell nucleus MOTIF: Zn finger PHD-type NAME: Zn finger PHD-type SITE: 5-56 EFFECTOR-BOUND: Zn+2 binding site SITE: 193-193 FOR-BINDING-OF: alpha-ketoglutarate JmjC {197-353} MOTIF: binding site SITE: 246-246 FOR-BINDING-OF: alpha-ketoglutarate Iron [Fe]-binding site SITE: 249-249 Iron [Fe]-binding site SITE: 251-251 binding site SITE: 259-259 FOR-BINDING-OF: alpha-ketoglutarate binding site SITE: 266-266 FOR-BINDING-OF: alpha-ketoglutarate Iron [Fe]-binding site SITE: 321-321 binding site SITE: 321-321 FOR-BINDING-OF: alpha-ketoglutarate binding site SITE: 323-323 FOR-BINDING-OF: alpha-ketoglutarate Ser phosphorylation site {S458} Ser phosphorylation site {S459} proline-rich region SITE: 472-518 MOTIF: proline residue (SEVERAL) lysine-rich region {487-648} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S539} Ser phosphorylation site {S681} Ser phosphorylation site {S738} Ser phosphorylation site {S882} Ser phosphorylation site {S899} threonine-rich region {960-1020} MOTIF: threonine residue (SEVERAL) Ser phosphorylation site {S1056} AT-rich interactive domain-containing protein 5B COMPARTMENT: cell nucleus MOTIF: ARID {318-410} DNA-binding motif

References

UniProt :accession O75151

Components

AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B, Mrf1-like, modulator recognition factor 2, MRF-2, ARID5B, DESRT, MRF2) PHD finger protein 2; lysine-specific demethylase PHF2; GRC5 (PHF2, KIAA0662)