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protein Jade-1 (PHD finger protein 17, PHF17, JADE1, KIAA1807)
Function:
- transcriptional coactivator
- facilitates acetylation of nucleosomal histone H4 by HTATIP
- facilitates apoptosis
- renal tumor suppressor (putative)
- isoform 3 interacts with VHL & HTATI
Structure:
- belongs to the JADE family
- contains 2 PHD-type zinc fingers required for transcriptional activity
Compartment: cytoplasm, nucleus
Alternative splicing: named isoforms=3
Expression:
- expressed in kidney > pancreas, liver, heart
Pathology:
- down-regulated in renal cancer cells
General
zinc finger protein
Properties
SIZE: MW = 96 kD
entity length = 842 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 203-253
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 312-371
EFFECTOR-BOUND: Zn+2
serine-rich region {544-550}
MOTIF: serine residue (SEVERAL)
Database Correlations
UniProt Q6IE81
Pfam PF00628
References
UniProt :accession Q6IE81