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PHD finger protein 11; BRCA1 C-terminus-associated protein; renal carcinoma antigen NY-REN-34 (PHF11 BCAP)
Function:
- positive regulator of Th1-type cytokine gene expression
- interacts with BRCA1 & RELA
Structure: contains 1 PHD-type Zn+2 finger
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- highly expressed in T-cells & B-cells
- also expressed in NK cells & mature dendritic cells
- expressed at higher levels in Th1 cells as compared to Th2 cells
- expressed at low levels in all normal tissues tested, including lung, testis, small intestine, breast, liver & placenta
Polymorphism:
- variation in PHF11 seems to be associated with a propensity to childhood atopic dermatitis & asthma
General
PHD finger protein
Properties
SIZE: entity length = 331 aa
MW = 38 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 107-159
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM correlations
UniProt Q9UIL8
Entrez Gene 51131
Kegg hsa:51131
References
UniProt :accession Q9UIL8