prohibitin-2; B-cell receptor-associated protein BAP37; repressor of estrogen receptor activity; D-prohibitin (PHB2, REA, BAP)

Function: - mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (putative) - estrogen receptor selective coregulator a) potentiates inhibitory activities of antiestrogens b) represses activity of estrogens - competes with NCOA1 for modulation of estrogen receptor transcriptional activity. - role in regulation of mitochondrial respiration activity (putative) - role in aging vs terminal differentiation (see expression) - interacts with PHB, ESR1, HDAC1 & HDAC5 Structure: belongs to the prohibitin family Compartment: - mitochondrial inner membrane - cytoplasm (putative), nucleus - cytoplasmic & nuclear (putative) - levels of expression in fibroblasts decrease heterogeneously during cellular aging (terminal differentiation) - expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle - induced following inhibition of mitochondrial protein synthesis by thiamphenicol

General

mitochondrial membrane protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 33 kD entity length = 299 aa COMPARTMENT: mitochondria cytoplasm cell nucleus MOTIF: silencer element SITE: 19-49 Tyr phosphorylation site {Y128} silencer element SITE: 150-174 coiled coil {190-238}

Database Correlations

UniProt Q99623 Pfam PF01145

References

UniProt :accession Q99623