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PfSEA-1 protein
Pathology:
- Plasmodium falciparum schizont egress antigen-1 (PfSEA-1)
- 244 KD parasite antigen expressed in schizont-infected erythrocytes
- role in parasite replication by promoting schizont rupture [1]
- antibodies to PfSEA-1 may confer immunity to malaria
Pharmacology:
- potential target for malaria vaccine [1]
References
- Raj DK et al.
Antibodies to PfSEA-1 block parasite egress from RBCs and
protect against malaria infection.
Science 2014 May 23; 344:871
PMID: 24855263