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peroxisomal membrane protein PEX16; peroxin-16; peroxisomal biogenesis factor 16 (PEX16)
Function:
- required for peroxisome membrane biogenesis
- may play a role in early stages of peroxisome assembly
- can recruit other peroxisomal proteins, such as PEX3 & PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER)
- may function as receptor for PEX3 interacts with PEX19
Structure: belongs to the peroxin-16 family
Compartment:
- peroxisome membrane; multi-pass membrane protein
- endoplasmic reticulum membrane
Alternative splicing: named isoforms=2
Pathology:
- defects in PEX16 are the cause of peroxisome biogenesis disorder complementation group 9
- defects in PEX16 are a cause of Zellweger syndrome (ZWS)
General
peroxisomal membrane protein (peroxin)
Properties
SIZE: entity length = 336 aa
MW = 39 kD
COMPARTMENT: peroxisome
endoplasmic reticulum
MOTIF: cytoplasmic domain {1-84}
MOTIF: peroxisomal location {66-81}
transmembrane domain {85-105}
Peroxisomal {106-110}
MOTIF: exoplasmic loop {106-110}
transmembrane domain {111-131}
cytoplasmic domain {132-336}
MOTIF: PEX19 interaction {221-336}
Database Correlations
OMIM correlations
MORBIDMAP 603360
UniProt Q9Y5Y5
Pfam PF08610
Entrez Gene 9409
Kegg hsa:9409
References
UniProt :accession Q9Y5Y5