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peroxisome biogenesis factor 10; peroxin-10; peroxisome assembly protein 10; peroxisomal biogenesis factor 10; RING finger protein 69 (PEX10, RNF69)
Function:
- somewhat implicated in the biogenesis of peroxisomes
- interacts with PEX19
Structure:
- belongs to the pex2/pex10/pex12 family
- contains 1 RING-type Zn+2 finger
Compartment: peroxisome membrane
Alternative splicing: named isoforms=2
Pathology:
- defects in PEX10 are the cause of peroxisome biogenesis disorder complementation group 7
- defects in PEX10 are a cause of
a) Zellweger syndrome (ZWS)
b) neonatal adrenoleukodystrophy
General
peroxisomal membrane protein (peroxin)
ring finger protein
Properties
SIZE: entity length = 326 aa
MW = 37 kD
COMPARTMENT: peroxisome
MOTIF: RING-finger {273-311}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Database Correlations
OMIM correlations
MORBIDMAP 602859
UniProt O60683
PFAM correlations
Entrez Gene 5192
Kegg hsa:5192
References
- UniProt :accession O60683
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=PEX10
- dbPEX, PEX gene Database
http://www.dbpex.org/home.php?select_db=PEX10