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persistent depressive disorder
Clinical manifestations:
- presence of symptoms >= 2 years without remission lasting > 2 months
- symptoms generally mild
- other symptoms of depression (at least 2 for diagnosis)
- difficulty concentrating or making decisions
- low energy, fatigue
- sleep disorder: insomnia or hypersomnia
- overeating
- low self eseeem
- increased risk of suicide
Differential diagnosis:
- major depression
- episodic, periods of remission
- symptoms more severe
Management:
- selective serotonin reuptake inhibitor plus psychotherapy
- both are effective, but the combination is more effective than either alone [1,2,3]
General
depression
References
- NEJM Knowledge+ Psychiatry
- Schramm E, Klein DN, Elsaesser M, Furukawa TA, Domschke K.
Review of dysthymia and persistent depressive disorder: history, correlates,
and clinical implications.
Lancet Psychiatry. 2020 Sep;7(9):801-812
PMID: 32828168 Review.
- Patel RK, Rose GM
Peristent Depressive Disorder
Stat Pearls. NLM, June 26, 2023
https://www.ncbi.nlm.nih.gov/books/NBK541052/