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peroxisome

Peroxisomes or microbodies contain enzymes that oxidize D-amino acids, uric acid & various 2-OH fatty acids using O2 with formation of H2O2. Catalase present in microsomes can dismutate H2O2 to O2 & H2O, & catalyze oxidation of various compounds by H2O2. Peroxisomes also contain enzymes involved in lipid metabolism, particularly the oxidation of very long chain fatty acids & the synthesis of glycerolipids & plasmalogens. Microbody proteins are synthesized on free polysomes & imported post-translationally. Unlike import of proteins into mitochondria, chloroplasts or the ER/secretory pathway, import into microbodies does not generally require the removal of a presequence, but in part relies on the microbody C-terminal targeting signal (CMTS). Zellweger syndrome is a result of an absence of peroxisomes.

Related

microbody-targeting signal or peroxisomal-targeting sequence peroxisomal disorder peroxisomal membrane protein (peroxin) peroxisome proliferator-activated receptor (PPAR) peroxisome proliferator; PPAR agonist; PPAR gamma agonist

General

organelle

Properties

SIZE: WIDTH = 0.3-1.5 UM

References

  1. Textbook of Biochemistry with Clinical Correlations, 3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 21
  2. prosite :accession PS00342