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peritoneal carcinomatosis
Etiology:
1) ovarian cancer
- women with peritoneal carcinomatosis of unknown primary have ovarian cancer until proven otherwise
2) salpingo-oophorectomy reduces risk of cancer in patients with BRCA1 mutations; however, peritoneal carcinoma histologically indistinguishable from ovarian cancer may develop
Genetics:
- associated with BRCA1 mutations
Clinical manifestations:
- weight loss
- ascites [1]
Laboratory:
- in patients with ovarian cancer or unknown primary, serum CA125 can be useful in monitoring response to therapy
Management:
1) if no primary neoplasm is identified, treat women as if they have stage III ovarian cancer
- surgical debulking including salpingo-oophorectomy, hysterectomy, omentectomy, appendectomy, lymphadenectomy followed by chemotherapy [1]
2) prognosis: 5 year survival is 15-20% [1]
General
carcinomatosis
References
- Medical Knowledge Self Assessment Program (MKSAP) 14,16.17
American College of Physicians, Philadelphia 2006,2012, 2015
- Muggia FM, Baranda J.
Management of peritoneal carcinomatosis of unknown primary
tumor site.
Semin Oncol. 1993 Jun;20(3):268-72.
PMID: 8503022