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perindopril (Aceon, Coversyl)
Tradename: Aceon.
Indications:
- hypertension
- heart failure
- diabetic nephropathy, nondiabetic proteinuric nephropathy
- atherosclerosis [2]
- myocardial infarction
Dosage:
1) usual dose is 4-8 mg PO QD
2) higher doses are not much more effective
Tabs: 2, 4 & 8 mg.
Mechanism of action:
1) see ACE inhibitor
2) may prevent progression of atherosclerosis (8 mg/day) [2]
-> treating 50 patients for 4 years seems to prevent 1 major cardiovascular event [2]
Clinical trials:
- EUROPA trial
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with ACE inhibitors
Related
EURopean trial On reduction of cardiac events with Perinopril in stable coronary Artery disease (EUROPA) trial
General
angiotensin-converting enzyme (ACE) inhibitor
Properties
INHIBITS: angiotensin converting enzyme
MISC-INFO: pregnancy-category D
Database Correlations
PUBCHEM correlations
References
- Prescriber's Letter 6(10):56, Oct, 1999
- Prescriber's Letter 10(10):59 2003
Component-of
amlodipine/perindopril