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period circadian protein homolog 3; hPER3; cell growth-inhibiting gene 13 protein; circadian clock protein PERIOD 3 (PER3)
Function:
- component of the circadian clock mechanism which is essential for generating circadian rhythms
- function unknown
- phosphorylation appears to require association with PER1 & translocation to the nucleus (putative)
- ubiquitinated (putative)
- homodimer.
- component of the circadian core oscillator
- interacts directly with PER1, PER2, CRY1, CRY2, & TIMELESS
- interaction with CSNK1D or CSKN1E promotes nuclear location of PER proteins
Structure:
- contains 1 PAC (PAS-associated C-terminal) domain
- contains 2 PAS (PER-ARNT-SIM) domains
Compartment:
- cytoplasm (putative), nucleus
- mainly cytoplasmic
- translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2
- binding to TIMELESS does not lead to nuclear translocation
Alternative splicing: named isoforms=2
General
period circadian protein (hPER)
Properties
SIZE: entity length = 1201 aa
MW = 132 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PAS domain {121-188}
PAS domain {262-328}
PAC domain {337-380}
nuclear export signal {400-412}
CSNK1E binding domain {502-731}
MOTIF: serine-rich region {567-570}
MOTIF: serine residue (SEVERAL)
nuclear translocation signal {729-745}
serine-rich region {750-753}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 769-895
MOTIF: proline residue (SEVERAL)
serine-rich region {962-1081}
MOTIF: serine residue (SEVERAL)
CRY binding domain {1123-1201}
Database Correlations
OMIM 603427
UniProt P56645
PFAM correlations
Entrez Gene 8863
Kegg hsa:8863
References
- UniProt :accession P56645
- Entrez Gene :accession 8863