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peptide YY; PYY; PYY-I; peptide tyrosine tyrosine; contains: peptide YY(3-36), PYY-II (PYY)
Function:
- inhibits food intake at the level of the hypothalamus
- effect lasts at least 12 hours
- no effect on fluid intake, gastric emptying, serum insulin, serum glucose or leptin levels [2]
- inhibits exocrine pancreatic secretion
- has a vasoconstrictory action
- inhibitis jejunal & colonic peristalsis
Structure: belongs to the NPY family
Compartment: secreted
Alternative splicing: named isoforms=2
General
gastrointestinal hormone
secreted peptide
Properties
COMPARTMENT: extracellular compartment
Database Correlations
OMIM 600781
UniProt P10082
Pfam PF00159
Entrez Gene 5697
Kegg hsa:5697
References
- UniProt :accession P10082
- Journal Watch 22(18):142, 2002
Batterham RL et al, Nature 418:650, 2002
Schwartz MW & Morton GJ, Nature 418:595, 2002