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neuronal pentraxin-2; NP2; neuronal pentraxin II; NP-II (NPTX2)

Function: - likely to play role in the modification of cellular properties that underlie long-term plasticity - binds to agar matrix in a Ca+2-dependent manner (putative) Cofactor: binds 2 Ca+2 per subunit (putative) Structure: contains 1 pentraxin domain Compartment: secreted (putative) Expression: - expressed brain, pancreas, liver, heart & skeletal muscle - highest levels are seen in the testis Pharmacology: - recombinant pentraxin-2 may slow decline in lung function in patients with idiopathic pulmonary fibrosis [2]

General

pentraxin-2 (neuronal pentraxin, NPTX)

Properties

CONFIGURATION: pentamer SIZE: entity length = 431 aa MW = 47 kD MOTIF: signal sequence {1-15} N-glycosylation site {N148} N-glycosylation site {N189} Pentraxin {227-431} MOTIF: cysteine residue {C253} MODIFICATION: cysteine residue {C313} Ca+2-binding site SITE: 277-277 cysteine residue {C313} MODIFICATION: cysteine residue {C253} Ca+2-binding site SITE: 355-355 Ca+2-binding site SITE: 356-356 Ca+2-binding site SITE: 357-357 Ca+2-binding site SITE: 367-367 N-glycosylation site {N393}

Database Correlations

OMIM 600750 UniProt P47972 Pfam PF00354 Entrez Gene 4885 Kegg hsa:4885

References

  1. UniProt :accession P47972
  2. Raghu G, van den Blink B, Hamblin MJ et al Effect of Recombinant Human Pentraxin 2 vs Placebo on Change in Forced Vital Capacity in Patients With Idiopathic Pulmonary Fibrosis. A Randomized Clinical Trial. JAMA. Published online May 20, 2018 PMID: 29800034 https://jamanetwork.com/journals/jama/fullarticle/2681945 - Gibson KF, Kass DJ. Clinical Trials in Idiopathic Pulmonary Fibrosis in the "Posttreatment Era". JAMA. Published online May 20, 2018 PMID: 29800063 https://jamanetwork.com/journals/jama/fullarticle/2681942