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penicilloyl moiety (major determinant)
The penicilloyl moiety or major determinant results from reaction of beta-lactam ring with endogenous proteins. This forms a hapten-protein complex, the most abundant but not necessarily most immunogenic or allergic antigen resulting from beta-lactam antibiotics.
Related
adverse drug reaction (ADR)
cephalosporin
penicillin
General
antigen
References
Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998