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penicillin V (Pen-Vee K, Veetids, V-Cillin K, Aoracillin-B, Beepen VK, Lanacillin VK, Ledercillin VK, Robicillin VK, Wincillin-VK)
Tradenames: Pen-Vee K, Veetids. 1st generation penicillin.
Indications:
- moderate to severe susceptible bacterial infections
- upper respiratory tract infections
- pharyngitis
- sinusitis
- gingivostomatitis
- skin or soft tissue infections
- urinary tract infections
- antibiotic prophylaxis for:
- pneumococcal infection
- rheumatic fever
- treatment of otitis media
Dosage:
1) 250-500 mg PO QID
2) pharyngitis alternate 1000 mg PO BID x 10 days
3) Children: 25-50 mg/kg/day divided QID
Tabs: 125, 250, 500 mg.
Elixir: 125 & 250 mg/5 mL.
Antimicrobial activity:
- Streptococcus pyogenes
- Staphylococcus aureus (MSSA)
Adverse effects:
1) common (> 10%)
- mild diarrhea, nausea/vomiting, oral candidiasis
2) uncommon (< 1%)
- convulsions, fever, hemolytic anemia, positive direct antiglobulin (Coomb's) test (DAT), acute interstitial nephritis, hypersensitivity reactions, anaphylaxis
Interactions
drug interactions
General
penicillin
Properties
MISC-INFO: elimination route KIDNEY
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference