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pemphigus vegetans
Pemphigus generally confined to intertriginous regions, perioral area, neck & scalp.
May evolve into or from pemphigus vulgaris.
Epidemiology:
- rare
Pathology:
1) suprabasal acantholysis with intra-epidermal abscesses containing mostly eosinophils
2) pseudoepitheliomatous hyperplasia of the epidermis
3) IgG autoantibodies as in pemphigus vulgaris
Clinical manifestations:
- flaccid blisters that become erosions
- can form fungoid vegetations
- intertriginous regions, perioral area, neck & scalp
Interactions
disease interactions
Related
acantholysis
pemphigus vulgaris
General
pemphigus
References
- Color Atlas and Synopsis of Clinical Dermatology, Common
and Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY,
1997, pg 402
- Apalla Z, Sotiriou E, Lazaridou E et al
Pemphigus vegetans of the tongue: a diagnostic and therapeutic challenge.
Int J Dermatol. 2013 Mar;52(3):350-1
PMID: 23414160