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pemphigus
Etiology:
1) pemphigus foliaceus (mildest form)
2) pemphigus vulgaris
3) paraneoplastic pemphigus
4) drug-induced
- thiols (D-penicillamine, captopril, gold salts, pyritinol)
- amoxicillin, ampicillin, cephalosporin
- rifampin
Epidemiology: rare
Clinical manifestations:
1) vesiculobullous lesions
2) flaccid fragile blisters that progress to large, weeping denuded areas
3) oropharyngeal erosions are common
4) chronic disorder
5) see specific types
Laboratory:
- skin biopsy
- direct immunofluorescence testing of perilesional skin
- histopathology of lesional skin
- see ARUP consult [2]
Interactions
disease interactions
Specific
benign familial pemphigus (Hailey-Hailey disease)
IgA pemphigus
paraneoplastic pemphigus
pemphigus foliaceus
pemphigus vegetans
pemphigus vulgaris
General
autoimmune bullous disease (... pemphigus, bullous pemphigoid)
References
- Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17.
American College of Physicians, Philadelphia 2009, 2012, 2015
- ARUP Consult: Pemphigus
The Physician's Guide to Laboratory Test Selection & Interpretation
https://arupconsult.com/content/pemphigus
- Kridin K.
Pemphigus group: overview, epidemiology, mortality, and comorbidities.
Immunol Res. 2018;66:255-70.
PMID: 29479654