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peginterferon
Attachment of a polyethylene glycol moeity to interferon-2 alpha or interferon-2 beta results in a longer half-life of the protein.
Contraindications:
- avoid in patients with depression
Laboratory:
- IFNL3 variation rs12979860 predicts response to PEG-interferon-alpha
Specific
peginterferon alfa 2a (Pegasys)
peginterferon alfa 2b (Pegintron)
General
chemically-modified protein
pharmaceutical interferon
References
- Journal Watch 21(2):14, 2001
- Department of Veterans Affairs, VA National Formulary
- Clinical Pharmacogenetics Implementation Consortium (CPIC)
guideline information for boceprevir, peginterferon alfa-2a,
peginterferon alfa-2b, ribavirin, telaprevir and IFNL3.
https://www.pharmgkb.org/guideline/PA166110235