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core-binding factor (CBF) or polyoma virus enhancer-binding protein-2 (PEBP2)
Function:
- binds to the core site of murine leukemia virus & also to enhancers of T-cell receptor genes
- PEPB2, apparently identical to core-binding factor binds to the enhancer of polyoma virus
- CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers & promoters, including
a) murine leukemia virus
b) polyomavirus enhancer
c) T-cell receptor enhancers
d) osteocalcin
e) osteopontin
f) bone sialoprotein
g) collagen-1 alpha-1
h) LCK
i) IL-3
j) GM-CSF promoters
General
transcription factor complex
Properties
COMPARTMENT: cell nucleus
SUBUNITS: core-binding factor [CBF]-alpha
core-binding factor [CBF]-beta
MOTIF: Breakpoint {165-166}
References
Liu et al Science 261:1041 1993
Components
core-binding factor [CBF]-alpha (PEBP2-alpha)
core-binding factor [CBF]-beta; polyomavirus enhancer binding protein 2 beta; PEBP2-beta; SL3/AKV core-binding factor beta; SL3-3 enhancer factor 1 beta (CBFB)