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PeBow complex
Function:
- required for maturation of 5.8S ribosomal RNA & 28S ribosomal RNA & & formation of the 60S ribosome
- the PeBoW complex also associates with the 66S pre-ribosome
Structure:
- subunits include: BOP1, PES1 & WDR12
- within the PeBoW complex BOP1 interacts directly with PES1 & WDR12
General
molecular complex
Properties
SUBUNITS: ribosome biogenesis protein BOP1
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T106}
Ser phosphorylation site {S126}
Ser phosphorylation site {S127}
WD repeat {411-450}
WD repeat {452-492}
WD repeat {532-576}
WD repeat {577-615}
WD repeat {618-657}
WD repeat {661-700}
WD repeat {716-745}
Pescadillo homolog
COMPARTMENT: cell nucleus
MOTIF: nucleolar localization {1-257}
MOTIF: 28S rRNA processing {1-54}
MAP1B interaction {306-415}
MOTIF: BRCA1 C-terminal (BRCT) motif
SITE: 322-415
glutamate-rich region {456-531}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S457}
Ser phosphorylation site {S488}
28S rRNA processing {539-588}
MOTIF: Tyr phosphorylation site {Y548}
WD repeat-containing protein 12
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Sufficient for nucleolar localization {98-423}
MOTIF: WD repeat {99-137}
WD repeat {138-180}
WD repeat {187-226}
WD repeat {255-293}
WD repeat {295-334}
WD repeat {340-380}
WD repeat {384-422}
References
UniProt :accession O00541
Components
Pescadillo homolog (PES1)
ribosome biogenesis protein BOP1 (block of proliferation 1 protein, BOP1, KIAA0124)
WD repeat-containing protein 12; ribosome biogenesis protein WDR12 (WDR12)