astrocytic phosphoprotein PEA-15; 15 kD phosphoprotein enriched in astrocytes; phosphoprotein enriched in diabetes; PED (PEA15)

Function: - blocks Ras-mediated inhibition of integrin activation & modulates the ERK MAP kinase cascade - inhibits RPS6KA3 - activities by retaining it in the cytoplasm (putative) - inhibits both TNFRSF6- & TNFRSF1A-mediated CASP8 activity & apoptosis - regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane & the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface - phosphorylated by protein kinase C & CaM kinase - phosphorylation is modulated by neurotransmitters or hormones - binds RPS6KA3, MAPK3 & MAPK1 - transient interaction with PLD1 & PLD2 (putative) - interacts with CASP8 & FADD Structure: contains 1 DED (death effector) domain Compartment: - cytoplasm - associated with microtubules Expression: - ubiquitously expressed - most abundant in tissues such as heart, brain, muscle & adipose tissue which utilize glucose as an energy source - lower expression in glucose-producing tissues Pathology: - higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls

Properties

SIZE: entity length = 130 aa MW = 15 kD COMPARTMENT: cytoplasm MOTIF: death effector domain {3-81} MOTIF: Thr phosphorylation site {T6} Ser phosphorylation site {S25} Ser phosphorylation site {S61} binding site SITE: 98-107 FOR-BINDING-OF: microtubule MOTIF: Ser phosphorylation site {S104} Tyr phosphorylation site {Y108} Ser phosphorylation site {S116} binding site SITE: 122-129 FOR-BINDING-OF: microtubule

Database Correlations

OMIM 603434 UniProt Q15121 Pfam PF01335 Entrez Gene 8682 Kegg hsa:8682

References

UniProt :accession Q15121