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PDZ domain-containing protein 3 (intestinal & kidney-enriched PDZ protein, protein DLNB27, PDZD3, IKEPP, PDZK2)
Function:
1) regulatory protein that interacts with the C-terminal region of GUCY2C & negatively modulates its heat-stable enterotoxin- mediated activation
2) interacts with SLC34A1
Compartment:
- cell membrane, peripheral membrane
- apical surface of intestinal epithelial cells
Alternative splicing: named isoforms=5
Expression:
- expressed in kidney, gastrointestinal tract
- not expressed in brain, heart, skeletal muscle or hematopoietic cells
Related
PDZ (PSD-95 post-synaptic density protein, Discs large, Zona occludens tight junction protein) domain
PDZ domain-containing protein
General
other protein
Properties
SIZE: MW = 61 kD
entity length = 571 aa
MOTIF: PDZ domain
NAME: PDZ domain
SITE: 115-196
PDZ domain
NAME: PDZ domain
SITE: 223-301
PDZ domain
NAME: PDZ domain
SITE: 329-412
PDZ domain
NAME: PDZ domain
SITE: 467-548
Database Correlations
OMIM 607146
UniProt Q86UT5
Pfam PF00595
References
UniProt :accession Q86UT5