Contents

Search

PDZ (PSD-95 post-synaptic density protein, Discs large, Zona occludens tight junction protein) domain

Domain found in MAGK superfamily proteins/scaffold proteins of the postsynaptic density. They are modular domains of about 90 amino acid residues, specialized to binding of ES[D/E]V motifs found on the C-terminus of glutamate receptor epsilon subunits of the NMDA receptor. The PDZ domains of SAP-90 also interact with SynGAP1.

Related

PDZ domain-containing protein

General

binding site domain

Properties

NAME: PDZ domain

References

  1. Sheng M. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review. PMID: 11416187