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PDZ & LIM domain protein 5 (Enigma homolog, Enigma-like PDZ & LIM domains protein, PDLIM5, ENH)
Function:
1) role in the heart development by scaffolding PKC to Z-disk region
2) interacts with various PKC isoforms via LIM domains
3) interacts with actin & alpha-actinin via PDZ domain
Structure:
- contains 3 LIM zinc-binding domains
- contains 1 PDZ domain (DHR domain)
Expression: heart & skeletal muscle specific
Pathology:
- role in genetic susceptibility to schizophrenia
- PDLIM5 is commonly increased in the brain of patients with bipolar disorder, schizophrenia, & major depression
General
PDZ & LIM domain protein
Properties
SIZE: MW = 64 kD
entity length = 595 aa
COMPARTMENT: cytoplasm
MOTIF: PDZ domain
NAME: PDZ domain
SITE: 1-84
MOTIF: acetylation site
SITE: 1-1
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S227}
LIM domain {417-476}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {476-535}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {535-595}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Database Correlations
OMIM 605904
UniProt Q96HC4
PFAM correlations
References
UniProt :accession Q96HC4