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PDZ & LIM domain protein 2 (PDZ-LIM protein mystique, PDZ-LIM protein, PDLIM2)
Function:
1) adapter protein located at the actin cytoskeleton
2) promotes cell attachment
3) role in migratory capacity of epithelial cells
4) interacts with alpha-actinins ACTN1 & ACTN4, FLNA & MYH9
Structure:
- contains 1 LIM zinc-binding domain
- contains 1 PDZ domain (DHR domain)
Compartment:
- isoforms 1 & 2: cytoplasm, cytoskeleton
- isoform 3: nucleus. may be partially nuclear
- isoform 1 colocalizes with beta-1 integrin (ITGB1) & alpha-actinin but not with paxillin
Alternative splicing: named isoforms=4
Pathology:
- overexpression enhances cell adhesion to collagen & fibronectin & suppresses anchorage independent growth
- may contribute to tumor cell migratory capacity
General
PDZ & LIM domain protein
Properties
SIZE: MW = 37 kD
entity length = 352 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PDZ domain
NAME: PDZ domain
SITE: 1-84
serine-rich region {114-161}
MOTIF: serine residue (SEVERAL)
LIM domain {284-344}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Database Correlations
UniProt Q96JY6
PFAM correlations
References
UniProt :accession Q96JY6