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PDZ & LIM domain protein 1; Elfin; LIM domain protein CLP-36; C-terminal LIM domain protein 1 (PDLIM1, CLIM1, CLP36)
Function:
- cytoskeletal protein
- may act as an adapter that brings other proteins (like kinases) to the cytoskeleton
- interacts with alpha-actinins 1, 2 & 4
Structure:
- contains 1 LIM Zn+2-binding domain
- contains 1 PDZ domain (DHR domain)
Compartment:
- cytoplasm (putative)
- cytoskeleton (putative)
- associates with the actin stress fibers (putative)
Expression:
- strongly expressed in the heart & skeletal muscle
- moderately expressed in the spleen, small intestine, colon, placenta, & lung
- a lower level expression is seen in liver, thymus, kidney, prostate & pancreas
- not found in the brain, testis, ovary, or peripheral blood leukocytes
General
PDZ & LIM domain protein
phosphoprotein
Properties
SIZE: entity length = 329 aa
MW = 36 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
PDZ domain
NAME: PDZ domain
SITE: 3-85
Ser phosphorylation site {S90}
Ser phosphorylation site {S130}
Tyr phosphorylation site {Y144}
Tyr phosphorylation site {Y151}
Ser phosphorylation site {S186}
Ser phosphorylation site {S187}
Ser phosphorylation site {S239}
LIM domain {258-317}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
SITE: 260-260
Zn+2-binding site
SITE: 263-263
Zn+2-binding site
SITE: 280-280
Zn+2-binding site
SITE: 283-283
Zn+2-binding site
SITE: 286-286
Zn+2-binding site
SITE: 289-289
Zn+2-binding site
SITE: 307-307
Zn+2-binding site
SITE: 310-310
Tyr phosphorylation site {Y321}
Database Correlations
OMIM 605900
UniProt O00151
PFAM correlations
Entrez Gene 9124
Kegg hsa:9124
References
- UniProt :accession O00151
- NIEHS-SNPs
http://egp.gs.washington.edu/data/pdlim1/