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endoplasmic reticulum protein ER60; PDIA3; protein disulfide isomerase A3; 58 kD microsomal protein; 58 kDa glucose regulated protein (ERp57, ERp60)
Function:
- interacts with ERP27
- catalyzes the rearrangement of -S-S- bonds in proteins
Structure:
- belongs to the protein disulfide isomerase family
- contains 2 thioredoxin domains
Compartment:
- endoplasmic reticulum lumen (putative)
- melanosome
Note:
- originally thought to be a phospholipase C-alpha
General
protein disulfide isomerase (cellular thyroid hormone binding protein, prolyl 4-hydroxylase subunit beta, P4HB, ERBA2L, PDI, PDIA1, PO4DB)
Properties
SIZE: entity length = 505 aa
MW = 57 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-24}
thioredoxin domain
SITE: 26-133
MOTIF: cysteine residue {C57}
MODIFICATION: cysteine residue {C60}
cysteine residue {C57}
redox potential {58-58}
redox potential {59-59}
cysteine residue {C60}
cysteine residue {C60}
MODIFICATION: cysteine residue {C57}
Lowers pKa of C-terminal Cys of first active site {119-119}
thioredoxin domain
SITE: 377-485
MOTIF: cysteine residue {C406}
MODIFICATION: cysteine residue {C409}
cysteine residue {C406}
redox potential {407-407}
redox potential {408-408}
cysteine residue {C409}
cysteine residue {C409}
MODIFICATION: cysteine residue {C406}
electronegative {471-471}
ER retention {502-505}
Database Correlations
OMIM 602046
UniProt P30101
Pfam PF00085
Kegg hsa:2923
ENZYME 5.3.4.1
References
UniProt :accession P30101