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PDGF receptor-beta (PDGFRB)
Function:
- binds PDGF beta & PDGF alpha-beta
- soluble PDGFR-beta is a CSF biomarker of blood-brain-barrier associated capillary mural cell pericyte function [4]
Expression:
- pericytes, arterial smooth muscle cells
Pathology:
- diminished expression in Alzheimer' disease subtype 5
Interactions
molecular events
Related
PDGFR-beta Ag in tissue
PDGFRB gene rearrangement
General
oligomerizing protein
platelet-derived growth factor [PDGF] receptor
Properties
CONFIGURATION: dimer
SIZE: MW = 180 kD
COMPARTMENT: plasma membrane
STATE: active state
MOTIF: ligand-binding site
glycosylation site
immunoglobulin superfamily domain (4)
transmembrane domain
Tyr phosphorylation site
MOTIF-SEQUENCE: YIYV
kinase domain
SITE: KD1
MOTIF: ATP-binding site
NAME: ATP-binding site
Tyr phosphorylation site {Y740}
MOTIF-SEQUENCE: YMDM
Tyr phosphorylation site {Y751}
MOTIF-SEQUENCE: YVPM
Tyr phosphorylation site {Y857}
MOTIF-SEQUENCE: YMAP
kinase domain
SITE: KD2
MOTIF: ATP-binding site
NAME: ATP-binding site
Tyr phosphorylation site
MOTIF-SEQUENCE: YTAVQP
Tyr phosphorylation site {Y1021}
MOTIF-SEQUENCE: YIIPLP
Database Correlations
OMIM 173410
UniProt P09619
References
- Cross M, Dexter TM.
Growth factors in development, transformation, and tumorigenesis.
Cell. 1991 Jan 25;64(2):271-80. Review.
PMID: 1988148
- Koch CA, Anderson D, Moran MF, Ellis C, Pawson T.
SH2 and SH3 domains: elements that control interactions of
cytoplasmic signaling proteins.
Science. 1991 May 3;252(5006):668-74.
PMID: 1708916
- Pawson T.
Protein modules and signalling networks.
Nature. 1995 Feb 16;373(6515):573-80. Review.
PMID: 7531822
- Nation DA, Sweeney MD, Montagne A et al
Blood-brain barrier breakdown is an early biomarker of human
cognitive dysfunction.
Nature Medicine 2019. Jan 14.
PMID: 30643288
https://www.nature.com/articles/s41591-018-0297-y
Component-of
molecular complex