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platelet-derived growth factor [PDGF] receptor
Interactions
molecular events
Related
platelet-derived growth factor (PDGF)
Specific
CD140a; PDGF-R-alpha; alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen (PDGFRA)
PDGF receptor-alpha/beta
PDGF receptor-beta (PDGFRB)
General
glycoprotein
multisubunit protein
tyrosine kinase receptor (RTK)
Properties
COMPARTMENT: plasma membrane
STATE: active state
MOTIF: immunoglobulin superfamily domain (5)
transmembrane domain
kinase domain
SITE: KD1
MOTIF: ATP-binding site
NAME: ATP-binding site
Tyr phosphorylation site
kinase domain
SITE: KD2
MOTIF: ATP-binding site
NAME: ATP-binding site
References
- Nisheke et al Proc Natl Acad Sci USA (1990):87(1):424
- Matsui T et al,
Isolation of a novel receptor cDNA establishes the existence of
two PDGF receptor genes
Science 243:800 1989
PMID: 2536956
- Baron M, Norman DG, Campbell ID.
Protein modules.
Trends Biochem Sci. 1991 Jan;16(1):13-7. Review.
PMID: 2053133
- Koch CA, Anderson D, Moran MF, Ellis C, Pawson T.
SH2 and SH3 domains: elements that control interactions of
cytoplasmic signaling proteins.
Science. 1991 May 3;252(5006):668-74.
PMID: 1708916