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platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; proto-oncogene c-sis; Becaplermin (PDGFB, PDGF2, SIS)

Function: - growth factor - role in regulation of embryonic development, cell proliferation, cell migration, survival & chemotaxis - potent mitogen for cells of mesenchymal origin - required for - normal proliferation & recruitment of pericytes & vascular smooth muscle cells in the central nervous system, skin, lung, heart & placenta - normal blood vessel development - normal development of renal glomeruli - role in wound healing - signaling is modulated by the formation of heterodimers with PDGFA - homodimer; antiparallel disulfide-linked dimer - heterodimer with PDGFA; antiparallel disulfide-linked dimer - PDGFB homodimer interacts with PDGFRA & PDGFRB homodimers, & with heterodimers formed by PDGFRA & PDGFRB - the heterodimer composed of PDGFA & PDGFB interacts with PDGFRB homodimers, & with heterodimers formed by PDGFRA & PDGFRB - interacts with XLKD1 (putative) Structure: - belongs to the PDGF/VEGF growth factor family Compartment: - secreted - released by platelets upon wounding Expression: - expressed at high levels in the heart, brain (substantia nigra), placenta & fetal kidney - expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney & lung Pathology: - chromosomal translocation t(17;22)(q22;q13) involving PDGFB with COL1A1 is found in dermatofibrosarcoma protuberans Pharmacology: - available under the name Regranex (Ortho-McNeil) - used to promote healing in neuropathic diabetic foot ulcers

Related

sis proto-oncogene

Specific

becaplermin (Regranex)

General

oligomerizing protein platelet-derived growth factor (PDGF) sis family protein

Properties

CONFIGURATION: dimer SIZE: entity length = 241 aa MW = 27 kD COMPARTMENT: plasma MOTIF: cysteine-rich region MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*2} cysteine residue {*2} MODIFICATION: cysteine residue {*1} cysteine residue MODIFICATION: cysteine residue signal sequence {1-20} cysteine residue {C97} MODIFICATION: cysteine residue {C141} arginine residue {108} isoleucine residue {111} cysteine residue {C124} MODIFICATION: cysteine residue {C-INTERCHAIN} cysteine residue {C130} MODIFICATION: cysteine residue {C178} cysteine residue {C133} MODIFICATION: cysteine residue {C-INTERCHAIN} cysteine residue {C134} MODIFICATION: cysteine residue {C180} cysteine residue {C141} MODIFICATION: cysteine residue {C97} cysteine residue {C178} MODIFICATION: cysteine residue {C130} cysteine residue {C180} MODIFICATION: cysteine residue {C134} SECRETED-BY: macrophage

Database Correlations

OMIM correlations UniProt P01127 PFAM correlations Entrez Gene 5155 Kegg hsa:5155

References

  1. UniProt :accession P01127
  2. R&D systems' cytokine source book: PDGF http://www.rndsystems.com/molecule_detail.aspx?m=1967
  3. Regranex; Note: Clinical information on Regranex http://www.regranex.com/
  4. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/PDGFBID155.html
  5. Matsui T et al, Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes Science 243:800 1989 PMID: 2536956
  6. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908

Component-of

platelet-derived growth factor alpha/beta; PDGF-alpha/beta (PDGFA/PDGFB)