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platelet-derived growth factor (PDGF)
Function:
- PDGF stimulates tyrosine phosphorylation of the focal adhesion kinase (FAK) & paxillin & induces the association of PI-3-kinase with FAK [2]
Interactions
molecular events
Related
platelet-derived growth factor [PDGF] receptor
Specific
platelet-derived growth factor alpha/beta; PDGF-alpha/beta (PDGFA/PDGFB)
platelet-derived growth factor D (PDGF D, iris-expressed growth factor, spinal cord-derived growth factor B, SCDGF-B, PDGFD, IEGF, SCDGFB, MSTP036, UNQ1899/PRO4345)
platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor alpha polypeptide (PDGFA, PDGF1)
platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; proto-oncogene c-sis; Becaplermin (PDGFB, PDGF2, SIS)
General
cytokine
multisubunit protein
proto oncogene protein
Properties
COMPARTMENT: plasma
MOTIF: cysteine-rich region
MOTIF: cysteine residue {*1}
MODIFICATION: cysteine residue {*2}
cysteine residue {*2}
MODIFICATION: cysteine residue {*1}
cysteine residue
MODIFICATION: cysteine residue
SECRETED-BY: platelet
endothelial cell
References
- Hajjar DP & Pomerantz KB
Signal transduction in atherosclerosis: integration of
cytokines and the eicosanoid network.
FASEB J 6:2933 1992
PMID: 1644257
- Clark EA & Brugge JS
Integrins and signal transduction pathways: the road taken.
Science 268:233 1995
PMID: 7716514