Search
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; GMP-PDE gamma (PDE6G, PDEG)
Function:
- role in processes of transmission & amplification of the visual signal
- cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods & cones
- component of hetrotetramer composed of 2 catalytic chains (PDE6A, PDE6B), an inhibitory chain (PDE6G) & PDE6D
guanosine 3',5'-cyclic phosphate + H2O =guanosine 5'-phosphate
Structure:
- belongs to the rod/cone cGMP-PDE gamma subunit family
Pathology:
- defects in PDE6G are the cause of retinitis pigmentosa type 57
General
phosphodiesterase 6; rhodopsin-sensitive cGMP-specific phosphodiesterase (PDE6)
protein subunit
Properties
SIZE: entity length = 87 aa
MW = 10 kD
MOTIF: lysine-rich region {24-45}
MOTIF: lysine residue (SEVERAL)
active site
domain
MOTIF: histidine residue (2)
Database Correlations
OMIM correlations
UniProt P18545
Pfam PF04868
Entrez Gene 5148
Kegg hsa:5148
ENZYME 3.1.4.35
References
- UniProt :accession P18545
- Mutations of the PDE6A/B/G genes;
Note: Retina International's Scientific Newsletter
http://www.retina-international.com/sci-news/pdemut.htm
Component-of
photoreceptor cGMP phosphodiesterase