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phosphodiesterase 5; cGMP-specific phosphodiesterase
Function: hydrolyzes cGMP
Expression:
- expressed in high concentrations in the corpus cavernosum
Pharmacology:
- PDE5 is the target of sildenafil (Viagra) & other PDE5 inhibitors
Specific
cGMP-specific 3',5'-cyclic phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; CGB-PDE (PDE5A)
General
cyclic nucleotide phosphodiesterase
Properties
SIZE: MW = 93 kD
COMPARTMENT: cytoplasm
CELL: smooth muscle
platelet
spermatozoa
WITHIN: testis
MOTIF: active site
domain
MOTIF: histidine residue (2)