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phosphodiesterase 2 (PDE2) or cGMP stimulated phosphodiesterase
Also see phosphodiesterase 2A
Function:
- along with phosphodiesterase-1, major enzyme of CNS myelin
Expression:
- highly expressed in cortex, hippocampus, & basal ganglia, but not cerebellum
Specific
cGMP-dependent 3',5'-cyclic phosphodiesterase; cyclic GMP-stimulated phosphodiesterase; CGS-PDE; cGSPDE (PDE2A)
General
cyclic nucleotide phosphodiesterase
guanine nucleotide regulatory protein [GNRP] effector
lipoprotein
oligomerizing protein
phosphoprotein
Properties
SIZE: MW = 48 kD
MW = 105 kD
COMPARTMENT: cellular membrane
MOTIF: domain
MOTIF: histidine residue (2)
phosphorylation site
binding site
FOR-BINDING-OF: G-alpha
binding site
FOR-BINDING-OF: lipid
cysteine residue
MODIFICATION: palmitate
COMPARTMENT: membrane
References
- Whalin et al,
Second Messengers Phosphoproteins 1988-89;12(5-6):311-25
- Agrawal HC et al
2',3'-cyclic nucleotide-3'-phosphodiesterase in the
central nervous system is fatty-acylated by thioester linkage.
J Biol Chem 1990 Jul 15;265(20):11849-53
PMID: 2164018
- Vincent SR, Hope BT.
Neurons that say NO.
Trends Neurosci. 1992 Mar;15(3):108-13. Review.
PMID: 1373918
- Lincoln TM, Cornwell TL.
Intracellular cyclic GMP receptor proteins.
FASEB J. 1993 Feb 1;7(2):328-38. Review.
PMID: 7680013